908 Devices and CPI have formed a collaboration to develop cell culture media that will be optimized to allow for improved process control. 908 Devices, a US-based company specializing in chemical and biomolecular analytical devices, has formed a collaboration with CPI to optimize mammalian cell-culture media and feeding strategies. The aim of the project is to improve growth, protein titer, and protein quality attributes. Under the agreement, CPI researchers will employ 908 Devices’ REBEL desktop analytical device for at-line cell-culture media analysis, which will help to identify and subsequently control key process parameters in bioprocessing workflows, the companies stated in an April 21, 2022, press release. Currently, 908 Devices and CPI scientists are implementing at-line media analysis for a Chinese hamster ovary cell line expressing a monoclonal antibody in small-volume cell culture bioreactor systems through to process scale-up. The scientists are monitoring nutrient levels critical to process stability and product quality and are ultimately controlling outcomes through the design of media formulations and the implementation of optimized feeding strategies, according to the release.
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