Bruker offers highly multiplexed spatial proteomics, multiomic tissue imaging at large field-of-view


Bruker has announced large field-of-view highly multiplexed immunohistochemistry based on matrix-assisted laser desorption/ionization (MALDI HiPLEX-IHC) imaging of targeted proteins, overlaid with unbiased small molecule MALDI imaging on fresh frozen or formalin fixed paraffin embedded (FFPE) tissues, for spatial biology and cancer research. According to the company, MALDI HiPLEX-IHC is a breakthrough in multiomics imaging by combining targeted protein expression spatial profiling with unbiased small molecule MALDI imaging to co-localize proteins and small molecules such as glycans, lipids, metabolites, or xenobiotics. In addition to mapping tens to over 100 targeted proteins with high-plex peptide tags, MALDI HiPLEX-IHC can track signaling pathways such as glycosylation, observe lipid spatial profiles for tumor microenvironment segmentation, or simultaneously observe how drugs affect both protein and metabolic states.

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